Risk assessment of substances that are both genotoxic and carcinogenic

Harmonised approach for the risk assessment of compounds which are both genotoxic and carcinogenic

The European Food Safety Authority has prepared a draft for a harmonised strategy for the risk assessment of genotoxic and carcinogenic substances and presented this draft for discussion. The concept examines the exposure of the consumer to a specific substance and compares this with the carcinogenic effect of a defined dose in an animal experiment. Genotoxic and carcinogenic compounds are thus...

Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic.

This paper presents the work of an expert group established by the International Life Sciences Institute - European branch (ILSI Europe) to follow up the recommendations of an international conference on "Risk Assessment of Compounds that are both Genotoxic and Carcinogenic: New Approaches". Twelve genotoxic and carcinogenic chemicals that can be present in food were selected for calculation of...

Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: leucomalachite green.

Leucomalachite green (LMG) is mutagenic and produces DNA-adducts in vivo, and is carcinogenic in rodent bioassays. Dose-response modelling of the data for hepatocellular adenomas and carcinomas in female mice gave a BMDL10 of 20 mg/kg-bw/day. Limited data are available on the concentrations present in fish for human consumption. Human exposure estimates assumed that all consumed fish is contami...

Carcinogenic and Non-Carcinogenic Risk Assessment of Some Heavy Metals Due to Consumption of Raisin Produced in Malayer City

Carcinogenic and Non-Carcinogenic Risk Assessment of Some Heavy Metals Due to Consumption of Raisin Produced in Malayer City Eisa solgi1*, Tarokh khodadadi2 1Associate Professor, Department of Environment, Faculty of Natural Resources and Environment,  Malayer University 2Ph.D. Student of Environmental Pollution, Faculty of Natural Resources and Environment, Malayer University Abstract In...

Opinion of the Scientific Committee on a request from EFSA related to A Harmonised Approach for Risk Assessment of Substances Which are both Genotoxic and Carcinogenic (Request No EFSA-Q-2004-020)